Clear cell sarcoma is a rare form of cancer called sarcoma. Wide resection of both the mandibular and tongue base lesions was performed, and the pathologic diagnosis was clear cell odontogenic carcinoma. Familial nonvhl clear cell renal cell carcinoma ccrcc is a hereditary condition that increases the risk of the clear cell type of renal cell carcinoma kidney cancer. Review article pathogenesis and nomenclature of odontogenic. Formerly known as clear cell odontogenic tumor, a locally aggressive benign tumor in the who classification of 1992, it was renamed ccoc and classified among malignant tumors after the revision of this classification in 2005. Clear cell carcinoma definition of clear cell carcinoma by.
Most intraosseous carcinomas originate from the epithelial lining of odontogenic cysts, so they. An odontogenic tumor is a neoplasm of the cells or tissues that initiate odontogenic processes examples include. Clear cell odontogenic carcinoma ccoc is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring predominantly in posterior mandible during 5 th7 th decades with a female predilection. Clearcell carcinoma article about clearcell carcinoma by. Clear cell adenocarcinoma definition of clear cell. Tumor immune microenvironment characterization in clear cell. Odontogenic cysts can give rise to a variety of neoplasms. Also called clear cell adenocarcinoma and mesonephroma.
Orthopantomogram showing an illdefined radiolucency involving body of the right mandible. Clear cell tumours are found in a number of organs. On histologic grounds alone, major diagnostic differential considerations include but are not limited to squamous cell carcinoma with clear cell change, salivary gland tumors involving the lung eg, mucindepleted lowgrade mucoepidermoid carcinoma, myoepithelial tumors, or metastatic carcinomas with clear cells such as metastatic renal. Dec 12, 2006 clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5th7th decades and shows a female preponderance. Background clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women.
Clear cell adenocarcinoma is a type of adenocarcinoma that shows clear cells clear cell adenocarcinoma. The world health organization recognizes four categories of adenocarcinoma. Maxillary clear cell odontogenic carcinoma a rare entity. Clear cell odontogenic carcinoma mimicking a cystic lesion. Clear cell odontogenic carcinoma is a rare, malignant neoplasm of odontogenic epithelium. Postoperative radiation therapy was carried out to obviate the possibility of residual disease. It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases. In the whoiarc classification of head and neck pathology, this clinical entity had been known for years as the odontogenic keratocyst. Odontogenic keratocysts make up around 19% of jaw cysts.
The present report describes 2 cases of primary intraosseous squamous cell carcinoma. Clear cell carcinoma of the base of the tongue is a rare minor salivary gland neoplasm, and to our knowledge, the mr imaging appearance of this entity has not been described. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. Dec 12, 2006 clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5 th 7 th decades and shows a female preponderance. Pathogenesis and nomenclature of odontogenic carcinomas. Primary intraosseous squamous cell carcinoma arising in. Clear cell odontogenic carcinoma is a rare odontogenic tumor occurring in the anterior region of the mandible in 5th7th decades and shows a female preponderance.
Reported symptoms of clear cell odontogenic carcinoma. Rare forms were thought to occur in the gastrointestinal tract before they were discovered to be different and redesignated as gnet. The study of clear cell odontogenic carcinoma has been mentioned in research publications which can be found using our bioinformatics tool below. In the past, this lesion has been referred to as clear cell odontogenic tumor or clear cell ameloblastoma.
A 45 year old woman presented with a radiolucent left mandibular swelling associated with loss of teeth. It is a potentially aggressive tumor, capable of frequent recurrences and locoregional and distant metastases. Clear cell odontogenic tumor is a rare neoplasm of the jaws that histologically may be confused with metastatic renal cell carcinoma. Definition of clear cell carcinoma nci dictionary of cancer.
Squamous cell carcinoma scc derived from keratocystic odontogenic tumor is an extremely rare tumor that is limited to the jaws. The pathogenesis of this rare group remains still controversial and there have been many varied opinions over the classification of this rare group of lesions. It is a potentially aggressive tumour, capable of recurring frequently, locally invasive, and with distant metastases. Health, general head and neck cancer diagnosis head and neck tumors. Clear cell odontogenic carcinoma ccoc is often considered as a rare tumor, first described by hansen in 1985. He x 200 clear cell ameloblastoma or odontogenic carcinoma 389 fig. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. Here, we employ a gene expressionbased computational method to profile the infiltration levels of 24 immune cell.
Dentigerous cysts are one of the most common odontogenic cysts of the oral cavity. It is potentially aggressive, capable of frequent recurrences and locoregional and distant metastases. Squamous cell carcinoma arising from an odontogenic. Clear cell odontogenic carcinoma ccoc, clear cell odontogenic tumor previously called clear cell ameloblastoma considered benign by who of 1992, but due to its high potential for regional spread and distant metastases, it was reclassified as malignant in 2005. A 70yearold woman presented with a large painful radiolucent mandibular lesion from the right canine to the left angle area through the midline. Our goal is to present two new cases, summarize reported cases of clear cell odontogenic carcinoma ccoc, assess potential risk factors for recurrence, and propose definitive surgical and. Tumorinfiltrating immune cells have been linked to prognosis and response to immunotherapy. Ysts can show variable presentation under a microscope, and pathologists may have difficulty in differentiating microcystic or endodermal sinuslike structures from clear cell carcinoma. Clear cell odontogenic carcinoma ccoc, which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. Thus, it is important to have a list of em in ones head so one doesnt misdiagnose something. Hyalinizing clear cell carcinoma of the lung american. Reported cases of clear cell odontogentic carcinoma.
Sep 24, 2015 clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw. Clear cell odontogenic carcinoma ccoc is a rare intraosseous carcinoma of the jaw. Mandibular clear cell odontogenic carcinoma springerlink. Review article pathogenesis and nomenclature of odontogenic carcinomas. Mandibular clear cell odontogenic carcinoma ik jae kwon1, soung min kim1,2, emmanuel kofi amponsah2, hoon myoung1, jong ho lee1 and suk keun lee3 abstract background. Clear cell odontogenic carcinoma ccoc malignant epithelial odontogenic neoplasm also composed primarily of clear cells, which usually occurs in anterior mandible unlike hccc, the nests or cords may show focal palisading of basal cells ameloblastic. It is known to occur mainly in the soft tissues and dermis. Micrograph of an ovarian clear cell adenocarcinoma. Clear cell odontogenic tumor how is clear cell odontogenic.